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Prednisone may interact with estrogens and phenytoin. Prednisone is used in much higher doses than the levels of corticosteroids produced naturally by the body, and as such, the usual actions of corticosteroids become exaggerated and may be observed as side effects of this medicine. Prednisolone is used for treating several types of arthritis systemic lupus, allergic reactions, asthma and severe psoriasis.
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